摘要
本研究采用荧光分光法检测了新正天丸治疗前后的偏头痛患者血小板和血浆中5-羟色胺(5-HT)含量和比值的变化。结果表明:患者组与对照组比较,发作期患者血小板5-HT含量增加,血浆5-HT含量降低(P<0.05,P<0.01),血小板5-HT/血浆5-HT比值异常(P<0.01);间歇期血小板和血浆5-HT含量均增加(P<0.05,P<0.01),但血小板5-HT/血浆5-HT比值未见明显异常。经新正天丸治疗后发作期和间歇期血浆5-HT含量与治疗前同期比较均有明显改善(P<0.05),发作期血小板5-HT/血浆5-HT比值与治疗前比较也有明显恢复(P<0.05)。本研究证明偏头痛患者发作期血小板和血浆5-HT含量及其比值均异常,这种异常可能是其发病基础,提示新正天丸可能是通过影响血小板对5-HT的摄取、释放、代谢过程,使其保持在生理平衡状态而达到治疗偏头痛的作用。
Changes of 5-hydroxytryptamine(5-HT) content in platelet and plasma before and after New Zhengtian Pill(NZTP) therapy in migraine patients were assayed with fluorospectrophotometry.Results showed that during the period of attack, the platelet 5-HT level of patients in comparing with normal control group, was increased(P<0.05) but the plasma 5-HT level decreased(P<0.01) and the ratio of the platelet and plasma 5-HT was abnormal P<0.01. While during the intermittent period the 5-HT was increased both in platelet and plasma and the ratio of intra and extra-platelet 5-HT was normal. Also, in comparing with before treatment, the post-treatmental plasma levels of 5-HT in patients with or without acute attack were all increased, the above-mentioned 5-HT ratio was also resumed obviously(P<0.05). This study revealed that both the plasma 5-HT and platelet 5-HT levels and their ratio of patients in acute attack period were abnormal, which might be the pathogenetic basis of migraine. It suggested the mechanism of NZTP in treating migraine might be through its action on absorption, releasing and metabolism of 5-HT by platelet and maintaining a physiologic balance in them.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1996年第5期280-282,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
全军医药卫生"八五"攻关课题