赤芍对高脂兔血小板胞浆游离钙、红细胞膜Ca^（2＋）－Mg^（2＋）－ATP酶活性的影响

Effect of Paeonia lactiflora on Platelet Cytosolic Free Calcium and Erythrocyte Membrane Ca￣(2+)-Mg￣(2+)-ATPase Activity in Hyperlipid Rabbits

本研究观察了赤芍对高脂兔血小板胞浆游离钙（［Ｃａ２＋］ｉ）、红细胞膜钙－镁－ＡＴＰ酶（Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ）活性血清钙及血脂的影响。结果表明：血小板［Ｃａ２＋］ｉ含量赤芍组（２７６．２５±２７．００ｎｍｏｌ／Ｌ）显著低于高脂组（３９０．８８±７０．００ｎｍｏｌ／Ｌ），Ｐ＜０．０１；红细胞膜Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ基础及激活活性（μｍｏｌ·ｐｉ－１·ｍｇ－１·ｈ－１）赤芍组（０．７９±０．０５，１．３４±０．１０）明显高于高脂组（０．６５±０．０９，１．０４±０．１３），Ｐ＜０．０１。说明赤芍可提高高脂血症兔红细胞Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶基础及激活活性。

The effect of Paeonia lactiflora(PL) on platelet cytosolic free calcium and erythrocyte membrane Ca2+-Mg2+-ATPase activity in hyperlipid rabbits were observed. Results showed the level of platelet cytosolic free calcium in the PL group(276.25±27.00nmol/L) was significantly lower than that in the cholesterol group(390.88±70.00nmol/L), P<0.01, the basal and calmodulin-stimulated activities of erythocyte membrane Ca2+-Mg2+-ATPase in PL group (0.79±0.05 μmol· pi-1·mg-1·h-1 and 1 .34±0.10μmol· pi-1·mg-1·h-1) were higher than that in the cholesterol group (0.65±0.09μmol·pi-1·mg-1·h-1 and 1.04±0.13μmol·pi-1·mg-1·h-1).