复方青黛胶囊对银屑病表皮角朊细胞中c－myc表达的影响

Influence of Qingdai Compound Capsule(QDCC) on the Expression of c-myc in Psoriatic Keratinocytes

应用免疫组化法检测３０例寻常型银屑病患者服用青黛胶囊治疗前后角朊细胞中ｃ－ｍｙｃ的表达并与正常对照组１２例作对比，经统计学处理结果发现银屑病患者皮损处的表达水平明显增高，与正常对照组相比有显著性差异。治愈后其表达水平下降，与正常对照组无显著性差异。角朊细胞中ｃ－ｍｙｃ的表达水平与银屑病的病理改变明显相关。提示青黛胶囊治疗银屑病是通过降低表皮角朊细胞中Ｃ－ｍｙｃ的表达水平发生治疗效果。本研究为复方青黛胶囊治疗银屑病提供了实验依据。

In this immunohistochemical study the authors detected the expression of c-myc in keratinocytes (ECK) from 30 psoriatic patients before and after QDCC treatment and 12 normal subjects for control. The results showed that the ECK of patients before treatment was significantly higher than that in normal control, and its level was correlated with histopathological changes. After treatment the ECK was normalized. It is believed that QDCC could decrease the EKC in psoriatic patient and this effect probably was mediated by inhibiting c-myc expression. This study provided an experimental evidence for the application of QDCC in treating psoriasis.