摘要
了解中药汉防己甲素（Ｔｅｔ）和维拉帕米（Ｖｅｒ）对环孢素Ａ肾毒性（ＣｓＡ－ＮＴ）的防护作用。方法一组大鼠用ＣｓＡ５０ｍｇ·ｋｇ－１／ｄ灌胃７天导致急性ＣｓＡ中毒，另二组在给ＣｓＡ前，分别给Ｖｅｒ及Ｔｅｔ。结果ＣｓＡ中毒大鼠表现为血清肌酐升高３４．８％，Ｃｃｒ下降３９．４％，并出现近曲小管大片空泡变性。同时，肾皮质丙二醛（ＭＤＡ）含量显著升高，超氧化物歧化酶（ＳＯＤ）活性显著下降。给予Ｔｅｔ或Ｖｅｒ均能使上述肾功能和脂质过氧化指标明显改善，Ｔｅｔ还能减轻ＣｓＡ所致的组织学损害。
bjectiveToinvestigatetheeffectoftetrandrine(Tet),aChinesemedicinalherb,andverapamil(Ver)oncyclosporineAnephrotoxicity(CsA-NT)intherats.MethodsAdministeringCsA50mg·kg-1/dtoonegroupofratsbygavagefor7daysresultedinacuteCsApoisoning,othertwogroupsreceivedTetandVerbeforeCsA.Re┐sultsRatswithCsA-NThada34.8%increaseinserumcreatinineanda39.4%decreaseinCcr.Histologicalex-aminationdemonstratedanextensivevacuolizationinproximaltubule.Inaddition,renalcorticalmalondialdehyde(MDA)increasedsignificantly,buttheactivitiesofrenalcorticalsuperoxidedismutase(SOD)decreasedsignifi-cantly.Inprotectiveexperiment,valuesoftheparametersmentionedaboveweresignificantlyimprovedinTetandVergroup,andthehistologicaldamagewassignificantlyreducedinTetgroups.ConclusionTetcanprotectkid-neyfromCsA-NT.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1996年第4期217-220,共4页
Chinese Journal of Nephrology
