血清唾液酸检测对癌症诊断的临床价值

Clinical value of Serum Sialic Acid Assay in the Diagnosis of Human Cancer

作者测定了５７７例正常人和２４１例恶性肿瘤患者血清总唾液酸（ＴＳＡ）和血清脂质结合唾液酸（ＬＳＡ）的含量。结果表明：ＴＳＡ和ＬＳＡ的含量变化与疗效一致，治疗有效者ＴＳＡ和ＬＳＡ与正常人相比，均无显著性差异（Ｐ＞０．０５）；治疗无效（包括未经治疗）者与正常人相比除原发性肝癌、乳腺癌外均有显著性差异（Ｐ＜０．０１）。血清ＴＳＡ和ＬＳＡ测定对肺癌、胃癌、大肠癌等有临床诊断价值（Ｐ＜０．０１），对鼻咽癌诊断效果更好（Ｐ＜０．００１）。对肝癌、乳腺癌的诊断价值有限（Ｐ＞０．０５）。恶性肿瘤患者ＴＳＡ与ＬＳＡ含量间无相关关系（ｒ＝０．０９；Ｐ＞０．０５；ｎ＝１１７）。ＬＳＡ检测不能代替ＴＳＡ检测，两者应该联合检测以提高其阳性率。

Serum levels of total sialic acid(TSA) and lipid-bound sialic acid(LSA)were measured in 577 normal persons and 241 cancer patients respectively.The results showed:No significant difference was found in the serum SA(TSA/LSA)levels between normal persons and various cancer patients who had been treated effectively(P>.05).Significant difference(P<0.01)was found in the serum SA(TSA/LSA)levels between normal persons and various cancer(cancer of thelung,nasopharynx,stomach,intestines,etc) patients who had not been treated effectively.except hepatic or breast cancr.It is suggested that serum sialic acid(TSA/LSA)assay may be useful for diagnosis of lung cancer,gastric carcinoma,carcinoma of large intestine(P<0.01),especially for nasopharyngeal carcinoma(P<0.001),but less useful for hepatic carcinoma and breast cancer(P>0.05).No correlation was found between the serum TSA level and LSA level in cancer patients(r=0.09;P>0.05;n=117).LSA Assay can not replace TSA Assay in the detection of cancer.They should be measured together to raise the positive rate.