Ⅱ型糖尿病血清超敏C-反应蛋白与胰岛素抵抗的关系

The Relationship between Serum Hs-CRP,Insulin Resistance in Type II Diabetes.

目的探讨血清CRP与胰岛素抵抗之间的相关性及其临床意义。方法Ⅱ型糖尿病患者122例,测定其血清超敏CRP、空腹血糖(FPG)、空腹胰岛素(FINS)、甘油三酯(TG)、胆固醇(TCH)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、糖化血红蛋白(HbA1c)等生化指标。并测定每个病人的血压(收缩压SBP,舒张压DBP),体重指数(BMI)。计算胰岛素抵抗(IR)和胰岛素敏感指数(ISI)。结果高CRP组SBP、DBP、TG、BMI均显著高于正常CRP组(P<0.05),而高CRP组的HDL-C则显著低于正常CRP组(P<0.01)。血清超敏C-反应蛋白与各项指标之间的相关性分析表明,糖尿病病人血清hs-CRP与DBP、BMI、FPG、FINS、TG、UAI、R均存在显著正相关(P<0.05或P<0.01),hs-CRP与HDL-CI、SI之间则存在显著负相关(P<0.05)。结论糖尿病病人血清超敏CRP与胰岛素抵抗之间存在较好的相关性,CRP在糖尿病发生及发展中起一定的作用,超敏CRP可作为Ⅱ型糖尿病的一个早期协助诊断指标。

Objective To analyse the correlation between serum high- sensitivity C- reactive protein （hs- CRP） and insulin resistance in type Ⅱ diabetes, and discuss whether elevated serum hs - CRP level is associated with development of type Ⅱ diabetes. Methods In 122 patients with type Ⅱ diabetes, serum hs- CRP, FPG, FINS, TG, TC, HDL- C, LDL - C, UA, HbA1c, blood pressure and BMI were measured. Homeostasis model assessment （HOMA） and improved insulin sensitivity index （ISI） were applied to assess the status of insulin resistance （IR）. Results It was found that SBP, DBP, BMI, TG were significantly tfigher in elevated hs - CRP group than in normal hs - CRP group （P 〈 0.01 ）. Serum hs - CRP was positive correlated with DBP, BMI, FPG, FINS, TG, UA, IR in type Ⅱ diabetes （P 〈 0.05）, but was negative correlated with HDL - C and ISI （P 〈 0.05）. Conclusions There was positive correlation between Serum hs - CRP and insulin resistance in type Ⅱ diabetes. Elevated Serum hs - CRP predicted the development of type Ⅱiabetes.