T—2毒素、MON和硒对中国小型猪罹患骨软骨病的影响

EFFECTS OF T—2 TOXIN MONILIFORMIN AND SELENIUM ON OSTEO-CHONDROSIS OF CHINESE MINIPIG

中国小型猪在低硒(35ng/kg)饲料喂养条件下投给T—2毒素(1.5mg/kg饲料)或串珠镰刀菌素(MON,lmg/kg体重)105天,观察了动物前、后肢软骨的病理变化,首次证实所用的纯系农大Ⅰ号小型猪可以发生与家猪相同的骨软骨病(OC),出现三种类型OC损害。其中第三型损害(关节软骨深层带状、片状坏死)与T—2毒素和MON的投给关系明显,与单纯的低硒饲养无关;给毒的同时补给亚硒酸钠(使饲料含硒200ng/kg),未能防止这种损害发生,但能使病变的严重程度减轻。第一、二型OC损害的发生与毒素和硒的投给之间无明显规律性。本实验小型猪的OC—Ⅲ型损害与人类大骨节病的关节软骨损害相似,但骺板软骨未检见人类大骨节病那样的带状、片状坏死。

T-2 toxin (1. 5mg/kg feed) or moniliformin (MON, 1mg/kg body weight) was added to Se-deficient feed containing selenium 35 ng/kg for Chinese minipigs in a period of 105 days. The cartilage pathology of the rightfore and hindleg of these minipigs was observed. It was first demonstrated that Chinese minipig of pure ancestry BAU No. 1 can suffer from osteochondrosis (OC), which is identical with the OC occurring in domestic pigs. All three types of OC lesion were seen in these minipigs studied. And the type 3. OC lesion, i. e. zonal and patchy chon-dronecrosis in the deep layer of articular cartilage, was obviously relevant to the administration of T-2 toxin or MON, but not to the simple Se-deficient feeding. Along with toxin (T-2 toxin or MON) the supplementing of Na2SeO3 into the Se-deficient feed to increase the Se level to 200 ng/kg could alleviate the severity of the type 3. OC lesion, but could not prevent its occurrence. No any regular relationship between the type 1. /type 2. OC lesion and the administrating of toxins/selenium was seen. The type 3. OC lesion in this study was similar to the chondronecrotic lesions in the articular cartilage of human KBD. In KBD, chondronecrotic lesion could be seen in epiphyseal growth plate as well, but this could not be seen in the present study.