摘要
目的探讨胎粪吸入综合征(MAS)不同时相对新生儿局部脑组织氧饱和度(regional oxygen saturation,rSO2)的影响因素及合并缺氧缺血性脑病时脑组织氧饱和度变化的意义。方法根据MAS的临床表现分为无症状型、普通型、重型。应用TSNIR-3无创组织氧监测仪,测定其出生后1,3,5,7d时的脑组织氧饱和度变化,并与正常足月新生儿进行比较。结果MAS无症状型与正常对照组的rSO2在出生后第1天(58.37±4.12VS60.43±2.85)、第3天(57.76±2.33VS60.17±3.46)比较差异有显著性(P〈0.05);MAS普通型、重型生后的第1,3,5天时脑组织rSO2明显降低,MAS重型、普通型与无症状型、正常对照组的rSO2在出生后第1,3,5天比较差异有显著性(P〈0.05)。MAS合并轻度HIE组与中-重度HIE组比较,rSO2在发病的第1天差异无显著性意义(P〉0.05),第2,3,5天比较(57.60±3.60VS53.36±4.48;55.60±2.35VS51.36±3.20;56.80士2.78vs53.22±5.10)差异均有显著性意义(P〈0.05)。结论MAS患儿在生后的不同时相脑组织rSO2受到不同程度的影响,缺氧的加重和持续时间增加可使脑氧合功能进一步损害。
Objective This study examined the changes of regional cerebral oxygen saturation (rSO2 ) by noninvasive near infrared spectrophotometry in neonates with meeonium aspiration syndrome (MAS). Methods Seventy-three full neonates with MAS were divided into three groups by respiratory symptoms : asymptomatic group ( group 1, n = 38 ), common group ( group 2, n = 28 ) and severe group ( group 3, n = 7 ). Near infrared spectrophotometry was used to measure the cerebral rSO2 on days 1,3, 5 and 7 after birth. Thirty healthy full-term newborns served as the Control group. Results The cerebral rSO2 of group 1 decreased significantly compared with that of the Control group between days 1 and 3 ( P 〈 0.05 ). The cerebral rSO2 of group 2 or group 3 was significantly lower than that of group 1 and the Control group on days 1, 3 and 5 ( P 〈 0.05 ). The MAS patients with mild hypoxic-ischemic encephalopathy (HIE) had significantly higher brain rSO2 levels than those with medium or severe HIE on days 2, 3 and 5 ( P 〈 0.05 ). Conclusions The cerebral rSO2 decreased in neonates with MAS. The values for rSO2 correlate with the severity of HIE in MAS patients.
出处
《中国当代儿科杂志》
CAS
CSCD
2006年第3期191-194,共4页
Chinese Journal of Contemporary Pediatrics
基金
深圳市卫生科技立项课题(20040421)。
关键词
局部氧饱和度
脑
胎粪吸入综合征
新生儿
Regional oxygen saturation, cerebral
Meconium aspiration syndrome
Neonate