1[1]Janson J, Richanl AS, David H, et al. Humanislet anyloid polypeptide(hIAPP) cytotoxicty is caused by membrane damage[J]. Diabetes, 1998, 47(Suppl Ⅰ) :A250
2[2]Janson J Richard A, S, peter B, et al. The mechamism of islet anyloidpolypeptide toxicity ismembramedisruptionbyintermediatesized toxie amyloid particles[J] .Diabetes, 1999, 48:491 - 498
3Pratley RE,Foley JE ,Dunning BE. Rapid actingin sulinotropic agents :restoration of early insulin secretion as a physiologic approach to improve glucose control. Curr Pharm Des, 2001 ; 7 (14) :1375-1397.
4Malaisse WJ, Stimulation of insulin release by non-sulfonylurea hypoglycemic agents: The meglitinide family. Horm Metab Res, 1995,27:263-266.
5Yamato T, Ishikawa K, Ojima K, et al. Effects of KAD-1229 on postgrandial hyperglycemia after oral meal load in STZ-induced diabetic rats. Jpn J Pharmacol, 2001 - 85 (suppll) : AbstP-602.
6Misawa K, Ishikawa K, Oiima K, et al. Effects of KAD-1229,a nonsulfonylurea hypoglycemic agent,on plasma glucose and insulin in streptozotocin-induced diabetic dogs. Pharmacology.2001,62 (2) :65.
7Yamada N, Shigeta Y, Kaneko T,et al. Hypoglycemic effects and safety of a novel rapid-acting insulinotropic agent, KAD-1229, for NIDDM. Diabetes, 1996 ; 45 (Suppl 2) : Abst265.
8Ohnota H,Koizumi T,Tsutsumi N,et al. Novel rapld-and short-acting hypoglycemic agent, a calcium (2S)-2-benzyl-3- (cis-hexahydro-2-isoindolinylcarbonyl ) propionate (KAD-1229) that acts on the sulfonylurea receptor:Comparison of effects between KAD-1229 and gliclazide. J Pharmacol Exp Ther, 1994,269 : 489 - 495.
9Ohnota H, Kitamura T, Kinukawa M, et al. A rapid-and short-acting hypoglycemic agent KAD-1229 improves post-prandial hypoglycernic agent KAD-1229 improves post-prandial hyperglycemia and diabetic complications in steptozotocln-induced non-insulin-dependent diabetes mellitus rats. JPN J Pharmacol, 1996,71:315-323.
10Kawasaki T, Niikura M, Kobayashi Y. Fundamental study of hydroxyaptatite high - performance liquid chromatography. Ⅱ . Experimental analysis on the basis of the general theory of gradient chromatography[J]. J chromatogr, 1990, 515:91,125.
