苯巴比妥预防早产儿脑室内出血的探讨

Study of phenobarbital for the prevention of intraventricular hemorrhage in premature infants

目的:探讨苯巴比妥预防早产儿脑室内出血的效果。方法:以75例胎龄≤35周的早产儿为观察对象,预防组35例接受苯巴比妥负荷量的平均时龄为生后8.2小时,维持量5天。结果:预防组的脑室内出血发生率(31%)较对照组(46%)显著降低(P<0.01),同时生后6小时内接受负荷量的脑室内出血发生率(13.6%)较对照组显著降低(P<0.01),而生后6小时以后接受负荷量的脑室内出血的发生率(61.5%)较对照组降低不明显。结论:研究显示苯巴比妥可显著降低早产儿脑室内出血的发生率。建议对胎龄≤35周的早产儿生后6小时内常规应用苯巴比妥,以期降低早产儿脑室内出血的发生率。

Objective：To study the effect of Phenobarbital for the prevention Of intraventricular hemorrhage in the premature infants. Methods：A randomized controlled trail was carried out in 75 infants with a gestational age ≤35 weeks,35 infants received phenobarbital as a treatment group and the other 40 as a control group,The mean age of infants being given loading of Phenobarbital was 8.2 hours.Results：The result showed that the severe intraventricular hemeorrhage occurred more frequently in infants without phenobarbital prophylaxis than in treatment infants（46% vs 31% ,P〈0.01）.Conelusion：The study confirmed that the phenobarbital might reduce the incidence of intraventricular hemorrhage.It is suggested that phenobarbital prophylaxis should be routinly carried out in all pretem infants with gestational age≤35 weeks with 6 hours after birth.