口服避孕药联合二甲双胍治疗多囊卵巢综合征临床分析

Clinical analysis of the curative effect of metformin combined with mawelon in women with PCOS

目的:观察口服避孕药联合二甲双胍治疗多囊卵巢综合征(PCOS)的疗效。方法:选择2003年1月￣2005年12月来我院门诊就诊的患者90例,随机分为3组,口服妈富隆联合二甲双胍治疗组(A组)30例,妈富隆治疗组(B组)30例,二甲双胍治疗组(C组)30例,用药时间3个月,前后比较测定患者黄体生成素(LH)、血清卵泡刺激素(FSH),辛酮(T)、空腹胰岛素(Fl)、空腹血糖(FBG)、餐后2小时血糖(SG2h),腰/臀比值(WHR)及体重指数(BMI),并计算LH/FSH。结果:3组血清T、LH和LH/FSH比值均较用药前明显降低,A组LH和LH/FSH比值较其余两组降低更显著(P<0.05)。A、C组的WHR和BMI较前显著下降(P<0.05);B组WHR增加,差异无统计学意义(P>0.05)。A组及C组服药后的FI、SG2h均较用药前明显下降(P<0.05),B组无变化,3组的FBG基本没变化。结论:妈富隆联合二甲双胍治疗多囊卵巢综合征比单用口服避孕药妈富隆或胰岛素增敏剂二甲双胍疗效更好。

Objectlve：To observe the curative effect of metformin combined with compound mawelon in patients with polyeystic ovarian syndrome（PCOS）.Methods：90 patients with PCOS were randomly divided into three groups （group A,B and C）.Group A（n=30） was treated with combination of mefformin with compound mawelon,group B （n=30） with mawelon ,and group C （n=30） with mefformin alone. The clinic feature,reproductive hormone,and insulin levels were observed before and after treatment.Results：After treatment for three months,in all groups,T,LH and LH/FSH in three groups all decreased significandy,and were lower in group A than those in groups B and C（P〉0.05） greups.BMI and WHR in groups A and C decreased significantly（P〈0.05）, BMI and WHR in group B increased a little,without statistical significant（P〉0.05）.FI and SG2h in groups A and C decreased significantly（P〈0.05）, but there was no change in group B.FBG in all groups had no changes.Conclusion：The PCOS patients treated with mefform combined with compound mawelon might be more effective than any one of them alone.