系统性红斑狼疮合并抗磷脂综合征患者外周血CD1d的表达

The expression of CDld in systemic lupus erythematosus patients with antiphospholipid syndrome

目的通过检测系统性红斑狼疮(SLE)合并抗磷脂综合征(APS)患者外周血单个核细胞(PBMC)CD1d表达,探讨CD1d分子和APS疾病和实验室指标的相关性。方法利用流式细胞分析方法对20例合并APS患者,30例SLE对照,23名正常对照PBMC CD1d表达进行分析,并与患者临床资料和实验结果进行相关分析。结果SLE合并APS组PBMC中CD1d表达高于正常对照组,和SLE对照组比较差异无统计学意义。SLE合并APS组单核细胞群中CD1d表达高于正常对照组,和SLE对照组比较差异无统计学意义。CD1d和SLE疾病活动指数(SLEDAI)评分显著相关,和补体明显呈负相关。结论CD1d表达异常与SLE发病相关,并可作为评价SLE活动的指标。

Objective To investigate the association of CD1d with APS and laboratory data, by examining the CDld expression of PBMC from systemic lupus erythematosus （SLE） patients with antiphospholipid syndrome. Methods The CD1d expression of 20 SLE patients with APS, 30 SLE controls and 23 normal controis were detected by flow cytometry. The relationship between CD1d expression and clinical, laboratory data of patients with SLE was analysed. Results The expression of CD1d in PBMC of SLE patients with APS was higher than normal controls, but had no difference with SLE controls. The expression of CD1d in monocyte group of SLE patients with APS was higher than normal controls, which had no difference with SLE controls. Highly significant correlations was found between CD1d expression and SLEDAI while, negative correlation between CD1d expression and complements was discovered. Conclusion The abnormal expression of CD1d may play a role in the pathogenesis of SLE, it may be a parameter for assessing disease activity.