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KIR3DS1与HLA-B^(Bw4)在广东汉族人群中的分布

Distribution of KIR3DS1 and HLA-B^(Bw4) in Guangdong Han People
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摘要 目的:研究K IR3DS1与HLA-BBw4正常广东汉族人群中的分布状态。方法:对92例广东汉族干细胞移植供者以序列特异性引物扩增技术(PCR-Sequence Spec ific Prim er)分析K IR3DS1和HLA-B表型;根据BW特异性分类,对HLA-BBw4第80位氨基酸残基为异亮氨酸者指定为HLA-BBw480ILE;依靠计算机软件进行K IR3DS1和HLA-BBw480ILE统计。结果:实验发现,在广东汉族人群中K IR3DS1、HLA-BBw4、HLA-BBw480ILE的表现频率依次为0.228,0.652,0.543;其中12.0%的个体为HLA-BBw4纯合子,14.1%的个体同时表现HLA-BBW 480ILE和K IR3DS1,另外有8.70%单独表现K IR3DS1而不表现HLA-BBw480ILE。结论:在广东汉族人群中,只有14.1%的个体同时表达HLA-BBw480ILE和K IR3DS1,而单独表达2K IR3DS为18.70%。 Objective： To investigate the distribution of KIR3DS1 and HLA-B^Bw4 in Guangdong Han people. Methods： 92 Guangdong Han bone marrow donors were studied. KIR3DS1 and HLA-B type were determined by polymerase chain reaction-sequence-specific-primer （PCR-SSP）. Denoted HLA-B^Bw4 with isoleucine located on 80th amino residual as HLA-B^Bw480^ILE. Coexpression or sole expression of KIR3DS1 and HLA-B^Bw480^ILE was counted using PC software. R^ults： Expression frequencies of KIR3DS1, HLA-B^Bw4 and HLA-B^Bw480^ILE in these Guangdong Han people were 0.228, 0. 652, 0. 542, respectively. Of the cases, 12.0% were HLA-Bs＇4 homozygotes, 14.1% coexpressed HLA-B^Bw480^ILE and KIR3DS1, and 8.7% expressed KIR3DS1 alone. Conclusion： In these Guangdong Hart people, only 14.1% co-expressed HLA-B^Bw480^ILE and KIR3DS1, and 8.7% expressed KIR3DS1 alone.
作者 肖露露 叶欣 尹晓林 郭坤元 马红京 尚振川
机构地区 广州器官移植配型中心 第一军医大学珠江医院血液科
出处 《广州医学院学报》 2006年第1期56-57,63,共3页 Academic Journal of Guangzhou Medical College
基金 广州市重大科研项目基金资助(2000-2-022-01)
关键词 杀伤免疫球蛋白样受体 人类白细胞抗原 killer immunoglobulin-like receptor human leukocyte antige
分类号 Q343.14 [生物学—遗传学]
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参考文献6

  • 1范丽安,颜卫华.非经典MHC Ⅰ类分子与免疫调节[J].上海免疫学杂志,2003,23(5):289-292. 被引量：8
  • 2Martin MP, Gao X, Lee JH, et al. Epistatic interaction between KIR3DSI and HLA-B Delays the progression to AIDS[J]. Nat Genet, 2002,31(4):429-34.
  • 3Flores-Villanueva PO, Yunis EJ, Delgado JC, et al.Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity [J]. Proc Natl Acad Sci USA, 2001,98(9):5140-5.
  • 4Hsu KC, Liu XR, Selvakumar A, et al. Killer lg-like receptor haplotype analysis by genecontent: evidence for genomic diversity with a minimum of six basic framework haplotypes, eachwith multiple subsets [J]. J Immunol,2002, 169(9):5118-29.
  • 5Vdehes C, Parham P. KIR: diverse, rapidly evolving receptors of innate and adaptiveimmunity [J]. Annu Rev Immunol, 2002, 20:217-51.
  • 6Celia M, Longo A, Fcrrara GB, et al. NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80 [J]. J Exp Med,180(4): 1235-42.

二级参考文献25

  • 1Ishitan A, Sageshima N, Dorofeeva N, et al. Protein expression and peptlde binding suggest unique and interacting functional roles for HLA-E, and G in maternal-placental immune recognition [ J]. Tissue Antigen, 2002,59 : 1.
  • 2Hayday AC.γδ T cells: a right time and a right place for a conserved third way of protection[J]. Annu Rev Immunol, 2000,18,975.
  • 3Polakova K, Russ G. Expressoin of the non-classical HLA-G antigen in tumor cell lines is extremely restricted[J]. Neoplasma, 2000,47:342.
  • 4Lila N, Amrein C, Guillemain R, et al. Human leukocyte antigen-G expression after heart transplantation is associated with a reduced incidence of rejection[J]. Circulation, 2002,105:1949.
  • 5Sasaki H, Xu XC, Mohanakumar T. HLA-E and HLA-G expression on porcine endothelial cells inhibit xenoreactive human NK cells through CD94/NKG2-dependent and independent pathways [J ]. J Immunol,1999,163:6301.
  • 6Ljunggren HG, Karre K In search of the missing self MHC molecules and NK cell recognition[J]. Immunol Today, 1990, 11:237.
  • 7Cohen GB, Gandhi RT, Davis DM, et al. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected ceils from NK cells[J]. Immunity, 1999, 10:661.
  • 8Schust DJ. Tortorella D. Ploegh HL. HLA-G and HLA-C at the fetomaternal interface: lessons learned from pathogenic viruses[J]. Semin Cancer Biol, 1999,9:37.
  • 9Allan SJ,Lepin EJ,Braud VM,et al.Tetrameric complexes of HLAE,HLA-F,and HLA-G[J]. J Immunol Methods, 2002, 268:43.
  • 10Matte C, Laeaille J, Zijenah L, et al. HLA-G and HLA-E polymorphisms in an indigenous Mriean population. The ZVITAMBO Study Group[J]. Hum Immunol, 2000, 61 : 1150.

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广州医学院学报
2006年 第1期

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