Relationships between mucinous gastric carcinoma, MUC2 expression and survival

瞄准：为了调查四的表示，在一系列胃的癌分泌了形成胶化的粘蛋白( MUC2 ， MUC5AC ， MUC5B 和 MUC6 )，分类 Lauren 的，素菜烩肉的，并且 Goseki 的分类，与到所有的特殊注意，不同部件(专业和未成年者)在肿瘤并且到介绍在临床的数据上面列在后面。方法：MUC2， MUC5AC， MUC5B 和 MUC6 的表示用免疫组织化学和原位杂交被调查。结果：在胃的癌的分泌形成胶化的粘蛋白的表示是特别地复杂的，各粘蛋白 being 没限制到平的任何组织病理学说的类型在一个给定的肿瘤认为所有部件(专业和未成年者) 是现在。在有粘液(Goseki II 或 IV ) 和高积极 MUC2 表示的一个更高的内容的病人有最糟的幸存。结论：在胃的癌症的粘蛋白基因表达式模式的复杂性可以在没在使用的词法分类系统认出的房间水平反映区别的一个精确状态。MUC2 的高表示不过与 WHO 分类的粘蛋白的子类型并且与 Goseki 一个特别肿瘤的主要部件识别的分类的组 II 被联系。粘液的数量和质量与幸存有关。

AIM： To investigate the expression of the four secreted gel-forming mucins （MUC2, MUCSAC, MUCSB and MUC6） in a series of gastric carcinomas, classified according Laurén＇s, Mulligan＇s, WHO and Goseki＇s classifications, with special attention to all the different components （major and minor） present in tumors and to follow up clinical data.METHODS： Expression of MUC2, MUC5AC, MUC5B and MUC6 was investigated using immunohistochemistry and in situ hybridization.RESULTS： Expression of secreted gel-forming mucins in gastric carcinoma was particularly complex, each mucin being not restricted to any histopathological type even considering all components （major and minor） present in a given tumor. There was a worst survival in patients with a higher content of mucus （Goseki Ⅱ or Ⅳ） and high positive MUC2 expression.CONCLUSION： Complexity of mucin gene expression patterns in gastric cancer may reflect a precise state of differentiation at the cell level not recognized in used morphologic classification systems. High expression of MUC2 was nevertheless associated with mucinous subtype of the WHO classification and with group Ⅱ of Goseki＇s classification identified by the major component of a particular tumor. The quantity and quality of mucus were related to survival.