脑外伤后尿崩症并重度低钠血症临床治疗方案的探讨

The Therapeutic Programmes of Transient Diabetes Insipidus after Cerebral Trauma Complicated by Hyposodemia

目的:探讨脑外伤后暂时性尿崩症并低钠血症的发生机理及治疗方法。方法:以限制入水量、补充高渗盐水及应用垂体后叶素为治疗方案的12例治疗组(以下简称“治疗组”)与20例常规治疗方案的对照组进行疗效对比研究。结果:治疗组治愈率66.70%,总有效率91.67%;对照组治愈率15.00%,总有效率40.00%。结论:治疗组强调入水量控制、积极纠正血浆低渗透压,刺激精氨酸加压素(AVP)释放,控制尿崩症,疗效明显优于对照组(P<0.01)。

Objective： To investigate the development mechanism and the treatment method of the transient diabetes insipidus after cerebral trauma complicated by hypodemia. Methods： In the treated group the water was limited to intake, the hypertonic saline was infused and hypophysin was used. The control group was treated with conventional therapy. The curative effects were compared between these two groups. Results： The cure rate of the treated group was 66.70%, and the total effective rate was 91.67%. The cure rate of the control group was 15.00%, and the total effective rate was 40.00%. Conclusion： In the treated group the diabetes insipidus can be controlled through regulating the water intake, and positively correcting the blood plasma hyposmolarity, also stimulate to release of AVP. The curative effect in treated group is better obviously than that in the control group （P 〈 0.01）.