母乳中部分胃肠激素对新生儿早发型母乳性黄疸的影响

Influence of Some Gastrointestinal Hormones in the Mother's Milk on Early Breast Milk Jaundice of Newborn

目的:探讨母乳中胃动素、胃泌素、生长抑素对新生儿早发型母乳性黄疸的影响。方法:应用放射免疫分析法对63例生后6d内的早发型母乳性黄疸患儿血中及其母亲乳汁中的胃动素(MTL)、胃泌素(GAS)和生长抑素(SS)浓度进行测定,并与39例生后6d内的正常新生儿进行对照。结果:母乳性黄疸患儿血中及其母亲乳汁中MTL、GAS水平均低于正常对照组且有显著性差异(P<0.001);患儿血中SS水平(47.5±18.6)ng/L虽低于正常对照组(51.4±22.8)ng/L,但无显著性差异(P>0.05);而患儿母亲乳汁中SS水平(31.9±11.7)ng/L则高于正常对照组(28.9±9.7)ng/L,但也无显著性差异(P>0.05)。结论:母乳中MTL、GAS偏低,外源性胃肠激素的摄入减少可能是早发型母乳性黄疸患儿血中MTL、GAS水平偏低及发生早发型母乳性黄疸的原因之一。

Objective： To investigate the effect of motilin, gastrin and matostatin levels in mother＇s milk on neonate early breast milk jaundice. Methods： Fasting serum and milk motilin, gastrin and matostatin leveLs were measured with radioimmunoassay in 63 neonates with early breast milk jaundice within postnatal six days. Fasting serum and milk mofilin, gastrin and matostatin levels from thirtynine normal term newborns within postnatal six days were used as controls. Results： The serum and milk motilin and gastrin levels in the early breast milk jaundice group was significantly lower than that of the controls （P 〈 0.001）. The serum and milk matostatin levels in the early breast milk jaundice group was not different from that of the controls. Conclusion： The milk motilin and gastrin levels was low. The decrease of ingestion of extrinsic gastrointestinal hormones is possibly the reason of the low level of serum motilin and gastrin in early breast milk jaundice group and the one of reasons of inducing early breast milk jaundice.