摘要
肿瘤化疗失败的主要原因是多药耐药(MDR)的产生。肿瘤多药耐药的机制十分广泛,其中以ATP结合盒式结构超家族成员研究较多。文章重点综述目前研究较多的多药耐药机制,并对肿瘤耐药逆转进展作简要介绍。
Multidrug resistance （MDR） of cancer cells is a major cause of failure in chemotherapy. The mechanism of multidrug resistance is vary, while much attention was paid on the expression of ABC （ATP binding cassette） transporter. This paper provides a review on the hotspots of current MDR research. Moreover, the recent progress in the field of MDR reversal is also briefly introduced.
出处
《中国肿瘤》
CAS
2006年第6期382-385,共4页
China Cancer
关键词
肿瘤
多药耐药
药物疗法
neoplasms
chemotherapy
multidrug resistance
