过渡金属催化的羰基化合物及含酸性氢化合物的α-芳基化反应

Transition-Metal Catalyzed α-Arylation of Carbonyl Derivatives and Compounds with Acidic Hydrogen

对钯等过渡金属催化的羰基化合物及含酸性氢化合物的α-芳基化反应的研究进展进行了论述。随着大位阻、富电子烷基膦和氮杂环卡宾(NHC)为配体的催化体系的出现,该类反应的底物已从酮扩展到醛、酯、酰胺以及含酸性氢的化合物如丙二酸酯、硝基化合物、腈、砜等。

Advances in the transition-metal catalyzed α-arylation of carbonyl derivatives and compounds with acidic hydrogen are reviewed. By using sterically hindered, electron-rich alkylphosphines and N-heterocyclic carbenes（NHC）, this process has encompassed a broad range of substrates including ketones, aldehydes, esters, amides, malonates, nitrocompounds, nitriles and sulfones.