恩丹西酮(欧贝)防治化疗所致呕吐的临床疗效分析

Clinical curative effect of Ondansetron of chemotherapy-induced emesis

目的观察恩丹西酮在含顺铂化疗过程中的作用,并与胃复安加地塞米松进行对比,观察其止吐疗效和副作用。方法将恩丹西酮用于既往化疗时用胃复安加地塞米松止吐仍出现呕吐的患者,采用自身对照法,分别给予恩丹西酮8mg静脉注入或胃复安20mg加地塞米松5mg静脉滴注。结果恩丹西酮控制呕吐的有效率为90%,胃复安加地塞米松的有效率为55%。结论恩丹西酮能有效控制化疗所引起的呕吐反应,并且副作用很轻微。

[Objective] To evaluate the efficacy and toxicity of Ondansetron for prevention of vomiting induced by patients receiving cisplatin chemotherapy, and it was compared with Maxolon plus DXM. [Methodsl An experiment was carried out in treating the vomitive patients whose vomit could not be controlled by Maxolon plus DXM during chemotherapy, a randomized oneslf trial was performed, and Ondansetron 8 mg iv; Maxolon 20 mg plus DXM 5 mg iv were given before combination chemotherapy. [Results] The anti-emetic response rate of the Ondansetron group was 90 percent and that of Maxolon plus is only 55 percent. [Conclusion] Ondansetron is effective in controlling emesis induced by chemotherapy, and side effects are mild.