咳嗽变异性哮喘与肺炎支原体感染的相关性

Corelation between Cough Variability Asthma and Mycoplasm Pneumonia Infection

目的 探讨咳嗽变异性哮喘（CVA）与肺炎支原体（MP）感染的关系。方法 随机选择CVA患者30例为观察组，30例同期就诊、年龄相仿的急性上呼吸道感染患者为对照组。应用颗粒凝集法测定两组患者MP—IgM。结果 观察组MP—IgM阳性12例，阳性率40％；对照组阳性4例，阳性率为13％，两组比较有显著差异（X^2=9．014，P〈0．01）。观察组MP-IgM滴度明显高于对照组，基保滴度≥1：320者占33．3％，而对照组较低，仅1例最高滴度为1：320。12例CVA并御感染的患者在常规治疗的基础上，加用大环内酯类口服。总有效率81.2％，随访6～24个月，无1例出现哮喘发作。结论 CVA与MP感染关系密切，对CVA患者应常规检测MP以排除MP感染，阳性者在按哮喘常规治疗同时予抗MP治疗，可取得满意效果。

Objective To discuss the relationship between cough variability asthma （CVA） and mycoplasm pneumonia （MP） infection. Methods 30 cases of CVA patient were taken as observing group and other 30 eases of URI patient as control group. The MP - IgM was detected in both groups. Results The positive rate of MP- IgM was 40% in observing group and 13% in control group with significant difference. The titer of MP- IgM in observing group was higher than that in control group （33.3% more than 1：320）. 12 eases of CVA combined with MP were treated with maerolide with total effective rate of 81.2% after 6 ～ 24 months follow- up without asthma reset. Conclusion There was dose relationship between CVA and MP infection. The CVA patient shottld be detected with MP and the MP positive patient should be treated as asthma and anti MP drug with good effect.