补气通络汤联合灯盏细辛治疗脑梗死61例

Buqitongluotang with Denzhangxixin Injection for Cerebral infarction

目的观察脑梗死病人采用补气通络汤合灯盏细辛治疗后的病灶变化及其临床效果。方法将119例脑梗死病人随机分为治疗组与对照组,分别于治疗前和治疗后30d行头颅CT扫描、临床神经功能缺损程度评分(SSS)、日常生活活动(ADL)量表评分以及纤维蛋白原(Fb)、凝血酶原时间(PT)和血小板计数(BPC)检测。结果治疗后CT显示治疗组病灶明显缩小,与对照组比较有统计学意义(P<0.05);两组治疗后SSS评分和ADL评分均较治疗前显著改善(P<0.01或P<0.05),且治疗组优于对照组(P<0.05);两组治疗后Fb明显下降(P<0.01或P<0.05),其中治疗组Fb下降较对照组更明显(P<0.05)。治疗组疗效明显优于对照组(P<0.05)。结论梗死灶吸收与临床疗效并不同步;治疗组较对照组具有更好的改善临床症状,促进缺损神经功能康复、抗凝、促纤溶以及促进短程梗死灶修复等综合作用。

Objective To explore the effects Buqitongluotang with Denzhangxixin Injection （BDI） on cerebral infraction. Methods A total of 119 patients （pts） with cerebral infraction were divided into two groups randomly：The mreatment group （n =61） treated by BDI with Denzhang xixin and control group （ n=58） treated by Denzhangxixin Injection for 30 days. Cerebral CT, SSS, ADL score, serum Fb, PF and BPC were tested. Results After treatment, the CT focus reduced significantly in the treatment group. The SSS and ADL ,score were improved significantly in two groups and that in the treatment group were superior to the control group. Serum Fb in the treatment groups was reduced significantly. The total efficacy rate in treatment group was 85.25 % and that in the control group was 62.07 % （ P 〈 0.05）. Conclusion Buqitongluotang with Denzhangxixin Injection was effective for Cerebral infarction.