60例慢性肾脏疾病患者血液流变学改变的研究

Research of changes of hemorrheology in 60 patients with chronic nephropathy

目的通过对60例慢性肾脏疾病患者血液流变学检测结果的分析,探讨其临床应用价值。方法应用国产XBH-31型旋转式粘度计和XH-10型血栓形成仪,对正常对照组、慢性肾小球肾炎、肾病综合征、慢性肾功能衰竭患者血液流变学指标进行检测并对结果进行分析。结果慢性肾小球肾炎、肾病综合征患者全血粘度、血浆粘度、血栓湿重及血栓干重高于正常对照组,具有统计学意义(P<0.01);慢性肾功能衰竭患者各项检测指标明显低于正常对照组,具有统计学意义(P<0.05)。结论慢性肾小球肾炎、肾病综合征发展过程中伴有血液流变学改变,血液凝固性增加,治疗中应注意采用抗凝疗法;慢性肾脏疾病发展到慢性肾功能衰竭时血液凝固性降低,治疗过程中应注意防治出血并发症。

Objective To analyze the changes of hemorrheology in 60 patients with chronic nephropathy and investigate the clinical application of hemorrheology. Methods The index of hemorrheology was detected in patients with chronic nephropathy by XBH-31 rotatory viscometer and XH-10 thrombosis inducer. The datas of hemorrheology were analyzed. Results The whole blood viscosity, plasma viscosity, weight of thrombosis were higher in the chronic glomerular nephritis, nephritic syndrome compared with control group（ P 〈 0.01 ）. The data of chronic renal failure was lower than control group （ P 〈 0.05 ）. Conclusion Blood viscosity is increasing during the process of chronic glomerular nephritis, nephritic syndrome. Antithrombin should be taken in treatment. Blood viscosity of chronic nephropathy complicated with chronic renal failure is low, the complication of hemorrhage should be paid attention to in treatment.