伊维菌素与甲硝唑治疗肠螨病的临床疗效比较

Clinical study of ivermectin/metronidazole in the treatment of patients with intestinal acariasis

目的比较伊维菌素与甲硝唑对肠螨病的治疗效果及安全性。方法选择症状典型且无并发症的肠螨病患者24例,分为两组,每组12例,采取双盲法分别试用伊维菌素和甲硝唑进行治疗,观察药物疗效。结果伊维菌素组患者按期服完3个疗程后,12例患者粪螨转阴性,临床症状基本消失,治愈率100%,服药后无明显不良反应。甲硝唑组患者按期服完3个疗程后,有3例粪螨转阴性,临床症状基本消失,其他症状亦明显缓解,5例临床症状减轻,4例无效,服药后2例患者有食欲下降、口干等不良反应。结论伊维菌素治疗肠螨病具有治愈率高、不良反应小、疗程短等优点,为治疗肠螨病的理想药物。

Objective To compare the efficacy and safety of ivermectin with metronidazole in patients with intestinal acariasis. Methods 24 patients with typical intestinal acariasis were selected and divided into two groups, each group had 12 members. Double-blind ,randomized clinical trial of ivermectin versus metronidazole was as.signed. Results 24 patients completed 3 courses. The total cure rate of ivermectin and metronidazole were 100% （12/12） and 25 % （3/12）, respectively. There was statistical difference between the two groups（ P 〈 0.01 ）. The incidence of adverse effects was 0（0/12） in the ivermectin treated group,and 17 % （2/12） in the metronidazole treated group. Conclusion Ivermectin is an effective and more safe drug for intestinal acariasis.