乙型肝炎病毒血清标志物测定及结果解释的若干问题

Key points in results explanation and detection of serological markers for hepatitis B virus infection

我国人群乙型肝炎病毒(HBV)感染率高,HBV感染血清学标志物是临床实验室最主要的检测项目之一。经对乙型肝炎“两对半”、抗HBc IgM和HBV DNA检测及结果解释中存在的一些普遍问题进行阐述,并注意到可能存在的因试剂方法的局限性、病毒变异等所致假阴性和假阳性,以及对检测结果的进一步确认和适当的解释,对HBV感染血清标志物检测的正确使用有重要意义。

Serological assay for hepatitis B virus （HBV） infection was the one of important parameters in China because of high prevalence of HBV. Here, some recommendations and reviews about detection of HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, anti-HBc IgM and HBV DNA and explanation of the results were presented. It is important for correct application of the serological markers of HBV infection that pay attention to false negative and false positive resulted from limitation of reagent kits and methods used, genome mutation of the virus and so on. Suitable explanation and further confirmation of the results also is a key point in serological detection of HBV infection.