早婴儿特应性皮炎发病因素探讨

The evaluations on some factors in the pathogenesis of infantile AD

目的观察纯母乳喂养特应性皮炎(atop ic derm atitis,AD)患儿皮损金黄色葡萄球菌(金葡菌)带菌率,与黄疸的相关性及乳母饮食对AD的影响,探讨以上因素在AD发病中的作用。方法AD皮损局部、非皮损局部分离金葡菌、经皮测定黄疸指数、乳母饮食随机分组,并与对照组进行统计学比较。结果与对照组相比,AD患儿皮损局部金葡菌与对照组金葡菌相比明显升高,黄疸与AD的发病无统计学意义,乳母饮食与AD有关。结论AD患儿皮损区带菌率45.00%,黄疸与AD的发病无相关性,乳母饮食情况参与AD发病。

Objectives To observe the prevalence of staphylococcus aureus （ S. Aureus） colonization in lesions of breast feeding childhood atopic dermatitis（AD） ,the correlation between the jaundice and AD,the impact on AD of the mothers＇ diet and to evaluate the roles of these factors in the pathogenesis of childhood AD. Methods Specimens were taken from the skin lesions of 60 patients, non - lesional skin of 30 Patients,and the skin of 30 controls for bacterial cultures. Determine icterus index through the skin ,grouping the mothers freely in to two groups ,one group（A） stop eating fish, eggs, milk and so on. The other group（ B ）eat as they do before. Results The prevalence of S. aureus colonization was significantly increased in the lesional skin of patients with AD in comparison with the controls （ p 〈 0. 05 ）. There was no significant difference in AD between the patients with and without jaundice （ p 〉 0.05 ）. The lesions decreased gradually while the A group ut dictum. Conclusions The results indicate that S. aureus could be isolated from 45.00% of AD lesions. There was no correlation between the AD and jaundice,the mothers＇ diet had influence on the pathogenesis of childhood AD.