冠心病患者血中壳三糖苷酶活性的研究

The Clinic Effects of Serum Chitotriosidase Activity in Patient with Coronary Heart Disease

目的研究冠心病患者血清壳三糖苷酶活性的临床意义。方法测定126例冠心病患者血清壳三糖苷酶的活性及其血脂水平,并与对照组相比较,分析其临床意义。结果在对照组、稳定性冠心病(SCHD)组和急性冠脉综合征(ACS)组壳三糖苷酶活性(nm o l/m l.h)分别为76.2±24.6,85.2±25.7,102.3±26.2。冠心病组显著高于对照组(分别为P<0.05、P<0.01),同时ACS组与SCHD组也存在显著差异(P<0.01)。结论壳三糖苷酶可以作为体内巨噬细胞激活的标志,反映动脉硬化症患者巨噬细胞的功能,检测其血清含量可能有助于稳定型心绞痛与不稳定型心绞痛的鉴别诊断。

Objective To discuss the clinic effects of serum chltotriosldase activity in patients with coronary heart disease. Methods Analyse its clinic effects by detecting the activity of serum chitotriosidase in 126 patients with coronary heart disease and comparing with control group. Results It showed that the activities of serum chitotriosidase in control group, stability coronary heart disease （SCHD） group and acute coronary syndrome （ACS） group were 76.2 ± 24.6,85. 2 ± 25.7 and 102.3± 26.2（nmol/ml · h） respectively. The levels of serum chitotriosidase were much higher in pathological group than in control group,and they were much higher in ACS group than in SCHD group（P〈0. 01）. Conclusion Chitotriosidase may be used to reflect the functions of macrophages in patients with artherosclerosis as the marker of activated macrophages. It can hypothesize that measuring the serum activity of chitotriosidase can lead to panorama of the functions of macrophages and the differentiation of SCHD and non-SCHD.