摘要
The synthesis of oestradiol compounds,which plays a very important role in biochemical test,is described in this paper.2-Hydroxide-17-deoxy-oestrone was synthesized from oestrone dy a three-step procedure:Wolff-Kishner reduction,acetylation and Dakin oxidation.(1) WolffKishner reduction: the yield of 17-deoxyestrone was 86.0%.(2)acetylation:the yield of 2-acetyl-deoxyestrone was 81.9%.(3) Dakin oxidation: the yield of 2hydroxied-17deoxy-oestrone was 91.2%
The synthesis of oestradiol compounds,which plays a very important role in biochemical test, is described in this paper. 2-Hydroxide-17-deoxy-oestrone was synthesized from oestrone dy a three-step procedure：Wolff-Kishner reduction, acetylation and Dakin oxidation. （ 1 ） Wolff-Kishner reduction： the yield of 17-deoxyestrone was 86. 0%. （2） acetylation ： the yield of 2-acetyl-deoxyestrone was 81.9%. （3） Dakin oxidation： the yield of 2-hydroxied-17deoxy-oestrone was 91.2%
出处
《化学研究与应用》
CAS
CSCD
北大核心
2006年第6期701-702,共2页
Chemical Research and Application
