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BCR-ABL持续表达在慢性粒细胞白血病急性变中的作用 被引量:1

Effect of BCR-ABL Persistent Expression in Chronic Myelogenous Leukemia Blast Crisis
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摘要 BCR-ABL持续表达可影响慢性粒细胞白血病细胞的生物学改变,促进白血病细胞的增殖、抑制细胞凋亡、阻断细胞分化、导致p53基因功能失活、c-myc基因表达增加及引起其他继发性染色体改变。该文就近年来BCR-ABL持续表达在慢性粒细胞白血病急性变中的作用的研究进展作一综述。
出处 《肿瘤学杂志》 CAS 2006年第3期245-247,共3页 Journal of Chinese Oncology
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  • 1Jing JG, Lalaine S, Beverly SM.Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl[J]. Blood, 2005,105:3270-3277.
  • 2Huettner CS, Zhang P, van Etten RA, et al. Reversibility of acute B-cell leukemia induced by BCR-ABL-1[J]. Nat Genet, 2000,24:57-60.
  • 3Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome[J].N Engl J Med,2001,344:1038-1042.
  • 4Clarkson B, Strife A, Wisniewski P, et al. Chronic myelogenous leukemia as a paradigm of early cancer and possible creative strategies[J]. Leukemia, 2003,17:1211-1262.
  • 5Prince G, Purva B, Srinivas A, et al. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3 [J].Blood,2005,105:1768-1776.
  • 6Honda H,Ushijima T,Wakazono K,et al. Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: a transgenic study for blast crisis of human CML[J]. Blood, 2000,95(4):1144-1150.
  • 7Datta A, Nag A, Pan W,et al.Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc[J]. J Biol Chem,2004,279(35):36698-36707.
  • 8Shet AS, Jahagirdar BN, Verfaillie CM. Chronic myelogenous leukemia: mechanisms underlying disease progression[J]. Leukemia, 2002,16(8): 1402-1411.
  • 9Sill H, Goldman JM, Cross NC. Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia [J].Blood, 1995,85:2013-2016.
  • 10Bruno C, Danilo P. The biology of CML blast crisis [J].Blood,2004,103(11):4010-4022.

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