苦瓜口含片降糖实验的研究

Study on the decreasing blood glucose by balsam pear tablets

目的:研究苦瓜口含片对高血糖小鼠的降血糖作用。方法:用四氧嘧啶诱发高血糖小鼠模型后,分别口服灌胃(ig)给予等体积的0.5%羧甲基纤维素钠溶液(空白对照组)、格列本脲片(阳性组,1mg·kg^(-1))、苦瓜口含片低(300mg·kg^(-1))、中(600mg·kg^(-1))、高(1200mg·kg^(-1))剂量组,连续给药30d 后,测定血糖值。结果:末次给药2h 后未测出明显的降糖作用,但在给药5h 后,阳性药和苦瓜口含片高剂量组(1200mg·kg^(-1))均有显著的降糖作用。结论:苦瓜口含片对高血糖小鼠具有明显的降糖作用。

Objective：To study the decreasing effects of balsam pear tablets on blood glucose in high blood glucose mice. Method ：The diabetic mice induced by alloxan model was established. The mice were andomly divided into the model group, glibenclamide group and different doses of balsam Pear tablets groups. After administered for 30 days, the diabetic mice were tested for the level of blood glucose. Result：No obvious blood glucose decreasing in any group after last administered for 2 h were tested, but remarkable blood glucose reducing had been tested in the glibenclamide group and high - dose of balsam pear tablets group after administration for 5 h. Conclusion ：The balsam pear tablets may have an obviously effect on decreasing the blood glucose for diabetic mice induced by alloxan.