吸烟对男性血清粘附分子和氧化应激的影响

Effect of man smoking on serum adhesion molecule and oxidative stress

目的分析吸烟对男性血清粘附分子和氧化应激的影响，为研究吸烟导致动脉粥样硬化和心血管功能障碍的发病机制提供流行病学依据。方法在2005年4-6月到某疾病控制中心体检的符合纳入标准的对象中随机抽取99名男性，调查其吸烟情况后根据分组标准分为：吸烟组43人。对照组56人，并分别检测其血清中可溶性细胞阎粘附分子（sICAM-1）浓度、可溶性血管细胞粘附分子（sVCAM-1）浓度、超氧化物歧化酶（SOD）的活力及总抗氧化能力（T-AOC）水平。结果吸烟组血清中sICAM-1的浓度为（855±294）ng／mL，高于对照组[（661±285）ng／mL]（P〈0．01）；吸烟组血清中T-AOC的浓度为（11．90±8．64）U／mL，低于对照组[（18．84±11．47）U／mL]（P〈0．01）；血清中sVCAM-1的浓度及SOD的活力，两组比较差异无统计学意义。相关分析表明，血清中sICAM-1浓度与吸烟指数呈正相关（r=0．621，P〈0．05）。结论吸烟对血清中粘附分子和氧化应激的影响有可能是吸烟导致动脉粥样硬化作用的机制之一。

Objective To observe the effect of man smoking on serum adhesion molecule and oxidative stress. Methods 99 male attendees at local CDC divided into smoking （43） and non-smoking （56） group were examined serum concentration of Intercellular adhesion molecule-1 （ ICAM-1 ） , Vascular endothelial adhesion molecule-1 （ VCAM-1 ） , Superoxide dismutase （SOD） , Total antioxidative capacity （T-AOC） respectively . Resets The sICAM-1 of smoking and nonsmoking group were 855 ±294 ng/mL and 661 ±285 ng/mL（P〈0.01）as well as T-AOC were 11.90 ±8.64 U/mL and 18.84 ±11.47 U/mL （P〈0.01）. There was no significant difference in sVCAM-1 and SOD between two groups whereas a significant correlated association in sICAM-1 by smoking index in smoking group （ r = 0. 621, P 〈 0. 05 ）. Conclusion Cigarette smoking influences serum adhesion molecule and oxidative stress which maybe results in Atherosclerosis .