盐酸戊乙奎醚用于麻醉前给药的可行性观察

Clinical investigation of penehyclidine hydrochloride used as a before-anesthesia prescription

目的观察盐酸戊乙奎醚作为麻醉前抗胆碱药的可行性。方法20一50岁病人40例，随机分为盐酸戊乙奎醚组（A组），东莨菪碱组（B组），每组20例。病人进入手术宣后肌肉注射盐酸戊乙奎醚0．01mg／kg（A组）或东茛菪碱0．3mg（B组）。记录入室后10min、注射后20min和45min三个时间点心率和血压。并与基础值对照，同时观察术前30min、手术开始后60min、术后10min病人面色、口干程度及分泌物情况。结果A组肌肉注射后心率、血压有轻微变化。与基础值比较差异无统计学意义（P〉O．05）；B组心率明显增快，与基础傀比较差异有统计学意义（P〈0，05）。两组病人面红、口干程度差异无统计学意义（p〉0．05），术中60min和术后10min拔管分泌物测量两组差异有统计学意义（p〈0．05）。结论盐酸戊乙奎醚不增加心率并且有较强减少痛人分泌物的作用。盐酸戊乙奎醚蛆作为麻醉前执肛碱药应是可行的。

Objective To investigate the feasibility of penehyclidine hydrochloride prescribed before anesthesia as a kind of anticholinergic drugs. Methods Forty patients aged 20 - 50 years were randomly divided into two groups：group A（ penehyclidine hydrochloride） and group B （scopolamine） with 20 patients in each group. After entered the operation room, patients were injected penehyclidine hydrochloride 0.01 mg/kg（ group A） or scopolamine 0.3 mg（ group B ）. Recorded heart rate （HR） and blood pressure （BP） at 10min alter entering operation room,20min and 45min after injection. Compared the result with base line value. Investigate the patientg complexion,degree of xerostomia and secretion at 30min before the operation,60min in the operacal significance compared with group B （ P〉0.05 ）. After intramuscular injection, HR increased significantly in group B than of group A（ P 〈0.05 ）. The degree of flame and xerostomia had no significant difference between the two groups （ P〉0.05 ）. There was significant difference on secretion after operation between the two groups （ P 〈0.05）. Conclusion Penehyclidine hydrochloride has great effect on reducing the patient＇s HR. It will be a good choice as anticholinergic drug administrated before anesthisa.