胆固醇酯转运蛋白活性测定在心脑血管疾病监测中的意义

Determination of cholesteryl ester transfer protein activity in patients with cardiocerebrovascular diseases

目的探讨胆固醇酯转运蛋白(CETP)活性与心脑血管疾病的关系。方法应用体外合成14C标记的高密度脂蛋白(HDL)样颗粒,测定了45例冠心病患者、26例脑卒中患者和40例健康人CETP活性。结果冠心病患者、脑卒中患者CETP活性分别为(17.6±5.4)%、(15.2±3.8)%,而健康人为(12.7±2.0)%,两组患者与健康人比较差异均有统计学意义(P<0.01)。结论CETP与动脉粥样硬化的发生、发展密切相关。

Objective To evaluate the relationship between the activity of cholesteryl ester transfer protein （CETP） and cardiocerebrovascular diseases. Methods The CETP activity of 45 cases of coronary heart disease （CHD） and 26 cases of stroke were measured using the synthetic substrate of ^14C-radio labeled discoidal bilayer particles as the cholesteryl ester donor and HDL as receptor, Results The CEPT activity （x^-±s） of CHD and stroke were （17.6±5.4）% and （15.2±3.8）% respectively, while the healthy controls were （12.7±2.0）%. The CEPT activities in the patients with CHD and stroke were significantly higher than that in the healthy controls （P〈0.01）. Conclusion CETP is related to the occurrence and development to atherosclerosis.