期刊文献+

内皮型一氧化氮合酶基因G894T多态性与临床疾病关系的研究进展 被引量:1

下载PDF
导出
摘要 一氧化氮的主要功能包括舒张血管平滑肌、阻止血小板的粘附和聚集、抑制血管平滑肌细胞增生等。内皮型一氧化氮合酶是位于血管内皮生成一氧化氮的限速酶。该酶的基因突变尤其是G894T位点的突变与多种临床疾病相关,现将其研究进展作一综述。
出处 《国际检验医学杂志》 CAS 2006年第6期532-533,536,共3页 International Journal of Laboratory Medicine
  • 相关文献

参考文献15

  • 1Furchgott RF. Endothelium-derived relaxing factor: discovery,early studies, and identification as nitric oxide. Biosci Rep,1999, 19(4): 235-251.
  • 2Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab, 2000, 70(4):241-251.
  • 3Tesauro M, Thompson WC, Rogliani P, et al. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci USA, 2000, 97(6): 2832-2835.
  • 4Jachymova M, Horky K, Bultas J, et al. Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy.Biochem Biophys Res Commun, 2001, 284(2): 426-430.
  • 5Wolff B, Grahe HJ, Schluter C, et al. Endothelial nitric oxide synthase Glu298Asp gene polymorphism, blood pressure and hypertension in a general population sample. J Hypertens, 2005, 23 (7):1361-1366.
  • 6Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med, 2005, 352(15):1585-1695.
  • 7Yoon S, Shin C, Park HY, et al. Endothelial nitric oxide synthase gene is associated with vessel stenosis in Korean population. Clin Chim Acta, 2005, 353(1-2): 177-185.
  • 8Colombo MG, Paradossi U, Andreassi MG, et al. Endothelial nitric oxide synthsse gcne polymorphisms and risk of coronary artery disease. Clin Chem, 2003, 49(3): 389-395.
  • 9Gorchakova O, Koch W, von-Beckerath N, et al. Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement. Eur Heart J,2003, 24(9): 820-827.
  • 10Park KW, You KH, Oh S, et al. Association of endothelial constitutive nitric oxide synthase gene polymorphism with acute coronary syndrome in Koreans. Heart, 2004, 90(3): 282-285.

同被引文献4

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部