氟康唑预防SAP合并疑似深部真菌感染

Prevention of suspicious deep fungal infection with severe acute pancreatitis with Fluconazole

目的探讨氟康唑预防重症急性胰腺炎(SAP)合并疑似深部真菌感染的效果。方法回顾性分析256例SAP患者,对其中有可疑临床表现但没有病原学证据的66例疑似合并真菌感染患者分为两组,氟康唑预防组42例和对照组24例。结果氟康唑预防组的深部真菌感染发生率4.8%,明显低于对照组45.8%,两组比较有显著性(P<0.05);氟康唑预防组和对照组发生深部真菌感染患者的病死率分别是4.8%和12.5%;对照组有1例致失明,而氟康唑预防组无致残者。结论深部真菌感染是SAP的严重并发症,发生率及死亡率均较高;预防性应用氟康唑可降低深部真菌感染发生率。

Objective To investigate the clinical character of patients with severe acute panereatitis（SAP） suspicious infected with deep fungal organisms and its prevention with Fluconazole. Methods Among 256 patients with SAP, 66 patients with suspicious deep fungal infection were randomized into 2 groups： fluconazole prevention group（42 cases） and control group（24 cases）. Results There were lower incidences of deep fungal infection in Fluconazole prevention group 4.8% than that in control group 45.8% （P〈0.05）. Mortality in Fluconazole prevention group and control group were 4.8% and 12.5% respectively. One ablepsia patient occurred in control group. There was no disability patient in prevention group. Conclusion Deep fungal infection is a severe complication of SAP, which has a high morbidity and mortality. It is important to carry out the prevention for suspicious deep fungal infection in SAP with Fluconazole.