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凋亡相关的斑点样蛋白ASC 被引量:4

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摘要 与凋亡相关的斑点样蛋白ASC是一种含胱天蛋白酶募集域和热蛋白样结构域的蛋白质,它与NF-кB、胱天蛋白酶-1(caspase-1)和热蛋白(pyrin)等多种分子有关,在炎症、细胞凋亡和肿瘤等方面发挥重要作用。
出处 《生命的化学》 CAS CSCD 北大核心 2006年第3期239-241,共3页 Chemistry of Life
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参考文献19

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  • 2Karin M et al. Semin Immunol, 2000, 12:85- 98
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同被引文献26

  • 1Masumoto J,Taniguchi S,Ayukawa K,et al.ASC,a novel 22 kDa protein,aggregates during apoptosis of human promyelocytic leukemia HL-60 cells[J].Biol Chem,1999,274(48):33835-33838.
  • 2Sethlik C,Sug L,Dorfleutner A,et al.Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation[J].J Immunol,2003,171(11):6154-6163.
  • 3Srinivasula SM,Poyet JL,Razmara M,et al.The PYRIN-CARD protein ASC is an activating adaptor for caspase-1[J].Biol Chem,2002,277(24):21119-21122.
  • 4Mariathasan S,Newton K,Monack DM,et al.Differential activation of the inflammasome by caspase-1adaptors ASC and Ipaf[J].Nature,2004,430(6996):213-218.
  • 5Masumoto J,Taniguchi S,Sagara J.Pyrin N-terminal homology domain and caspase recruitment domain-dependent oligomerization of ASC[J].Biochem Biophys Res Commun,2001,280(3):652-655.
  • 6Brough D,Rothwell NJ.Caspase-1-dependent processing of pro-interleukin-1 is cytosolic and precedes cell death[J].J Cell Sci,2007,120(5):772-780.
  • 7郭强,孔毅荣,付玲,徐俊杰,陈薇.炎性体研究进展[J].军事医学科学院院刊,2007,31(5):490-493. 被引量:7
  • 8Mariathasan S,Newton K,Monack DM. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf[J].Nature,2004,(6996):213-218.doi:10.1038/nature02664.
  • 9Yokoyama T,Sagara J,Guan X. Methylation of ASC TMSI,a proapoptotic gene responsible for activating procaspase-1,in human colorectal cancer[J].Cancer Letters,2003,(01):101-108.doi:10.1016/j.canlet.2003.08.027.
  • 10Fernandes-Alnemri T,Wu J,Yu JW. The pyroptosome:a supramolecular assembly of ASC dimers mediating in flammatory cell death via caspase-1 activation[J].Cell Death and Differentiation,2007,(9):1590-1604.doi:10.1038/sj.cdd.4402194.

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