维生素K_4、维生素D_2对绝经妇女骨折早期骨代谢的影响

INFLUENCE OF VITAMINS K4 AND D2 ON EARLY BONE METABOLISM IN MENOPAUSAL WOMAN FRACTURE: A Clinical Study

为探讨不同剂量水平的维生素K4及维生素D对绝经妇女骨折早期骨代谢的影响.选择年龄60～84岁（72.17±1.216岁）,绝经女性骨折病人35例,随机分为4组,分别给予不同剂量的维生素K4及维生素D口服,实验进行20天.通过观察患者服药前后血清钙、血清磷、血清碱性磷酸酶、血清凝血酶原时间及血清骨钙素值的变化,综合评价维生素K、维生素D对老年妇女骨折早期骨代谢的影响.结果显示,不同剂量水平维生素K4、维生素D对绝经妇女骨折早期骨代谢的影响不同,有统计学意义.维生素K4对骨代谢的影响作用超过维生素D,并随剂量水平不同而差异有显著性.但维生素K4、维生素D对骨代谢的影响无交互作用.表明维生素D、维生素K4能促进骨折早期骨代谢,对骨折愈合有一定促进作用,且维生素K的作用强于维生素D.

In order to study the influences of different doses of vitamins K4 and D2 on early bone metabolism in menopausal woman fracture, 35 cases of menopausal woman fracture aged 60 to 84 years (72.17±1.216 years) were selected and randomly divided into four groups, which were given different doses of orally-taken vitamins K4 and D2 for 20 days; the influences of vitamins K4 and D2 on early bone metabolism in senile woman fracture were comprehensively evaluated through observing the pre- and post-administration changes of calcium (Ca), phosphorus (P), AKP and prothrombin time (PT) in the serum. The results showed that varied doses of vitamins K4 and D2 produced different influences on early bone metabolism in menopausal woman fracture with a statistical significance; the influence of vitamin K4 exceeded that of vitamin D with a significant difference dependent on varied doses but the influences of vitamin K4 and vitamin D2 on bone metabolism had no interaction, suggesting that vitamins K4 and D2 function to stimulate early bone metabolism in fracture and have a certain stimulating effect on fracture healing; and the effect of vitamin K is stronger than that of vitamin D.