替卡西林钠的合成工艺改进

Improved synthesis of disodium ticarcillin

以氯乙酰氯为原料,经6步反应合成目标化合物,总收率27.7%。目标产物的光谱数据与文献报道一致。该工艺原料和试剂价廉易得,条件温和,反应总收率高,更适合工业化生产。

The target compound was synthesized via 6 steps from chloroacetyl chloride in 27.7% overall yield. Its spectral data were identical with those reported in literature. A more practical, effciently, economic process for synthesis of disodium ticarcillin is worked out.