佛山地区重症SARS病例存在抗SARS冠状病毒抗体

INVESTIGATION OF SERUM ANTIBODY AGAINST SARS CORONAVIRUS IN THE EARLIEST PATIENTS WITH SARS IN CHINA

目的:求证佛山地区首批临床诊断的SARS患者血清中是否存在抗SARS冠状病毒抗体。方法:以SARS冠状病毒全病毒裂解液作抗原,利用ELISA技术检测佛山地区首批出现急性呼吸窘迫综合征并具有明显传染特征的SARS康复患者和患者居住地“健康者”血清中抗SARS冠状病毒抗体。结果:4组有流行病学关系的19例SARS患者血清中抗SARS冠状病毒抗体全部阳性,而400名患者居住地的“健康者”血清中抗SARS冠状病毒抗体则全部阴性。结论:佛山地区首批SARS病例血清学调查结果发现在所有的患者血中均发现有抗SARS冠状病毒抗体,支持其病原体为SARS冠状病毒;抗SARS抗体IgG在SARS康复者血清中至少可存在6个月。

Objective. To identify the pathogen in the earliest patients with SARS in Foshan area. Methods： The lysate of whole SARS ooronavirus as antigen and ELISA were used to investigate serum antibody against SARS ooronavirus in the earliest patients with SARS in China who were characterized with infectivity and acute respiratory distress syndrome （ARDS） and in the healthy persons in this region. Results： Serum antibody against SAPS ooronavirus in the 4 groups of 19 cases were all positive; whereas that in 400 healthy control cases living in the same region were all negative. Conclusion： Investigation of serum antibody against SARS coronavirus in the earliest patients with SARS in China supports that SARS coronavirus as the pathogen of SARS. And the anti- SARS coronavirus antibody IgG in serum of the patients who recovered from SARS can persist at least 6 months.