立体定向放射治疗肺癌脑转移瘤200例疗效分析

CLINICAL RESULTS OF METASTATIC BRAIN TUMORS FORM LUNG CANCER IN 200 PATIENTS AFTER STEREOTACTIC RADIOTHERAPY

目的：探讨立体定向放射治疗肺癌脑转移瘤的方法及疗效。方法：2001年4月至2005年6月对200例肺癌脑转移病人进行立体定向放射治疗，单次靶区周边剂量为6-10Gy，总剂量为28-40Gy，分4-6次完成，70％～90％等剂量曲线覆盖病灶边缘。其中有176例配合全脑放疗。结果：全组病例随访6～57个月，平均26个月，临床缓解率为76．5％，肿瘤局部控制率为86．0％。1年生存率42％，3年生存率5％。无严重并发症出现。结论：立体定向放射治疗对肺癌脑转移瘤有确切的疗效，配合全脑照射，可以延长患者寿命，提高生存质量。

Objective： To study the technique and effect of stereotactic radiotherapy （SPT） on metastatic brain tumours from lung cancer. Methods： From March 2001 to June 2005, 200 patinets with metastatic brain tumors from lung cancer had been treated by using SRT. Single tumor dosage ranged from 6 Gy to 10 Gy in 4 to 6 fractions, total dose ranged from 28Gy to 40gy with rio serious complications occurred. 70% -90% dosage curve coveting the tumor edges. 176 of 200 patients were treated by whole brain radiotherapy （WBRT） before or after stereotactic radiotherapy. Results： The follow- up duration ranged from 6 - 57months （26months average）. Clinical syndromes were relieved in 153 cases （76.5%）. Local control （CR＋ PR） was obtained in 86% of 172 metastatic brain tumors from lung cacer. 84 of 200 （42%） patients survived for 12 months, and 10 of 200 （5%） patients survived for 3 years. Conclusion： Stereotactic radiotherapy can be used effectively in patients with metastatic brain tumors from lung cancer. For metastatic brain tumors lung cancer, combined SRT and WBRT can significantly improves survival time and life quality of the patients.