^（211）At标记单克隆抗体3H11及其Fab片段对裸鼠人胃癌移植瘤导向治疗的实验研究

Experimental study on￣(211)At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice

用α放射性核素２１１Ａｔ标记的抗胃癌单克隆抗体３Ｈ１１和它的Ｆａｂ片段进行了荷人胃癌裸鼠的实验性治疗研究。经腹腔注射１４．８或２２．２ｋＢｑ／ｇ鼠的标记单抗，每５天一次，连续三次。治疗结果表明，此单抗对肿瘤有较强的抑制作用，治疗１５天后疗效最显著，抑制率分别达６５％和７２％。未发现各重要器官有明显的辐射损伤。

Experimental radioimmunotherapy investigation of α-emitting radionuclide.211At labelled anti-gastric cancer monoclonal antibody 3H11 and its Fab fragment for nude mice carrying human gastric cancer xenografts was conducted.Three i.p.injections of 14.8 or 22.2 kBq/g mouse were given, once every 5 days.The results showed that the growth of tumor xenografts was inhibited efficiently.The most evident therapy effect was observed at 15 days after treatment,and the tnmor inhibition rates were 65% and 72%,respectively.No radiation injury of important organs was found.