骨骼病变患者血清中骨钙素与骨矿含量的研究

Study of serum osteocalcin and bone mineral density measurement in patients with osteal disorders

用放射免疫分析法测定了４６例骨骼疾病患者血清骨钙素含量，并与其中部分病例的骨矿含量、血清碱性磷酸酶、钙、磷等指标进行了比较，结果提示３２例原发性骨质疏松症患者和７例原发性甲状旁腺机能亢进患者血清ＢＧＰ均明显高于对照组（Ｐ＜０．０１），２例慢性肾衰患者的ＢＧＰ也高于正常组（Ｐ＜０．０５）；骨矿含量测定对诊断骨质疏松症等骨病有一定的参考价值。

Serum osteocalcin in 46 patients with osteal disorders was tested using radioimmunoassay (RIA).In some of cases, their forearm bone mineral density and serum AKP,calcimn and phosphorus were determined,and compared with osteocalcin.As a result,the osteocalcin level was higher than the normal controls in serum of 32 patients with primary osteoporosis(P<0.01),7 patients with primary hyperparathyroidism(P<0.01)and 2 patients with chronic renal insufficiency(P<0.05).Therefore serum osteocalcin and bone mineral density deterfornation have some value for the diagnosis of osteoporotic diseases.