获能期间精子蛋白的酪氨酸磷酸化

Protein tyrosine phosphorylation in sperm during capacitation

哺乳动物精了获能是精子与卵子成功受精的前提。蛋白酪氨酸磷酸化对精子获能十分重要。精了获能期蛋白酪氨酸磷酸化程度增高与sAC/cAMP/PKA途径、受体酪氨酸激酶途径和非受体蛋白酪氨酸激酶途径调节有关。获能过程中酪氨酸磷酸化蛋白分布于精子细胞的不同区域,蛋白的酪氨酸磷酸化与精子功能密切相关。

Mammalian sperm are required to undergo a process known as capacitation before they can undertake the fertilization process. The protein phosphorylation especially at tyrosine residues is one of the most important events that occur during capacitation. The increase in protein tyrosine phosphorylation during capacitation has been shown to be regulated by cAMP/PKA-dependent pathway, receptor tyrosine kinase pathway, and non-receptor protein tyrosine kinase pathway. It has been observed that the tyrosine phosphorylated proteins are localized in various regions of spermatozoon, and that the tyrosine phosphorylation of sperm proteins link to the different sperm functions.