不同起搏模式对AT-Ⅲ、FPA、PF_4和β-TG的影响及意义

Change and significance of AT_3,FPA,PF_4 and β-TG in different model permanentpacing patients

目的探讨永久心脏起搏早期及不同起搏模式对血浆抗凝血酶Ⅲ(ATⅢ)、纤维蛋白肽A(FPA)、血小板因子4(PF4)和血小板β球蛋白(βTG)的影响及意义。方法对30例植入永久心脏起搏器患者,根据起搏模式分为两组,其中心室按需(VVI)型组(V组)15例,双腔(DDD)起搏器组(D组)15例。测定其术前当天、术后7d的ATⅢ、FPA、PF4、βTG。结果术后ATⅢ较术前明显降低,FPA较术前明显升高。PF4、βTG较术前升高且V组升高较D组明显。结论本研究说明心脏起搏器植入后(1)凝血系统失衡,抗凝降低,凝血增强;(2)血小板活性增强,单腔起搏较双腔起搏更明显。

Objective To investigate the effect of different model of permanent pace maker on AT3, FPA, PF4 and β-TG at early period.Methods 30 permanent cardiac pacing patients were divided into two groups according to pacing medel.There were 15 patients with VVI pacemaker （group V） and 15 patients with DDD pacemaker （group D） .The levels of AT3 ,FPA,PF4 and β-TG in 30 patients were detected before and 7 day after pacing. Results After pacing AT3 decreased,however,FPA increased. PF4 and β-TG obviously increased in group V,as compared with those in group D. Conclusion （1） There is coagulation disorder in pacing patient. The activity of anticoagulant is decreased and coagulation is increased. （2） Platelet activation is increased after pacing and the WI model is more obvious than DDD model.