摘要
目的:进行了蟾酥固体脂质纳米粒冻干针剂大鼠体内的药代动力学研究。方法:采用RP-HPLC测定了大鼠体内不同时间的华蟾酥毒基、脂蟾毒配基浓度。结果:统计结果显示蟾酥固体脂质纳米粒冻干针剂与蟾酥水溶液的Cm ax、AUCextra、MRT均有显著性差异。结论:蟾酥固体脂质纳米粒冻干针剂能显著地延长蟾酥中华蟾酥毒基、脂蟾毒配基的体内滞留时间,固体脂质纳米粒有望成为改善水难溶性药物体内释放的新型制剂。
AIM ： To investigate the pbarmaeokinetics of lyophilization of toad venom （ Venenum Bufouis） -loaded solid lipid nanoparticles （Vs-SLN）. METHODS： Cinobufagin and resibufogenin plasma concentration in rat was determined by RP-HPLC. RESULTS： Statistic test showed that there was significant difference between lyophilization of Vs-SLN and Vs-injection for Cmax, AUCextra , MRT. CONCLUSION ： As the circulating time of the drug in blood was markedly prolonged, Vs-SLN can be developed to a novel preparation for controlled release of lipophil- ic drugs.
出处
《中成药》
CAS
CSCD
北大核心
2006年第6期787-790,共4页
Chinese Traditional Patent Medicine
基金
国家"863"计划项目(2004AA218021)
上海市纳米科技与产业发展促进中心项目(0352nml22)
