麝香保心丸对STZ大鼠心脏功能和病理变化的保护作用

Protectiv eeffect of Shexiang Baoxin Pills on the heart function and cardiac pathologic changes of STZ rats

目的:观察麝香保心丸对STZ大鼠心脏功能和病理变化的影响。方法:随机分为正常对照组、麝香保心丸组及STZ组。麝香保心丸组每天灌胃给约50mg/kg,第8周时测量心功能参数,同时采用电镜与免疫组化方法观察心脏病理形态学变化。结果:麝香保心丸可减少STZ大鼠的心肌间质纤维化:明显改善STZ大鼠心脏收缩和舒张功能。结论:麝香保心丸可改善STZ大鼠的心脏病理变化利心功能。

AIM：To observe the effect of Shexiang Baoxin Pills on pathologic changes and heart iunction of streptozotocin（STZ）-induced diabetic rats. METHODS： The rats were randomly divided into the control group, Shexiang Baoxin Pill group and STZ group. The rats in Shexiang Baoxin Pill group took Shexiang Baoxin Pill （50 mg/kg） to perfuse the stomach every day. The cardiac functions in 8 weeksafter treatment were determined. Meantime,the cardiac pathologic changes were observed through electron microscope and immunohistochemistry. RESULTS： Shexiang Baoxin Pills could reduce the interstitial fibrosis of myocardium in STZ rats. it could obviously improve the cardiac contraction and diastolic functions in STZ rats. CONCLUSION： Shexiang Baoxin Pills can amendment cardiac pathologic changes and improve cardiac function in STZ rats.