糖皮质激素及其受体在肾病综合征中的意义

SIGNIFICANCE OF GLUCOCORTICOIDS AND THEIR RECEPTORS IN PATIENTS WITH NEPHROTIC SYNDROME

应用受体放射分析技术检测了３４例肾病综合征（ＮＳ）患者及４０例对照组的外周血淋巴细胞糖皮质激素受体（ＧＣＲ）。结果显示：患者ＧＣＲ水平与糖皮质激素（ＧＣ）的疗效密切相关，对ＧＣ治疗敏感者，其ＧＣＲ水平高于对ＧＣ无反应者（Ｐ＜０．０１）及对照组（Ｐ＜０．０１）。同时检测了ＮＳ患者及对照组血浆促肾上腺皮质激素（ＡＣＴＨ）和皮质醇的含量，发现ＮＳ患者ＡＣＴＨ及皮质醇含量明显低于对照组（Ｐ＜０．０５），但与ＧＣ疗效未见明显相关性。

The glucocorticoid receptor (GCR) in 34 patients with nephrotic syndrome (NS) and 40 normal controls is investigated by radioligand binding assay. The results show that the GCR levels of NS patients are correlated well with the treatment results by glucocorticoids (GC). These patients who are sensitive to GC treatment have much higher levels of GCR than those who are not responsive to GC treatment ( P <0.01) and the normal controls. The plasma ACTH and cortisol in the same subjects are also measured and the results show that NS patients have much lower levels of these two hormones than the normal controls, but no significant correlation is noted between the levels and the GC treatment effects.