血清层粘连蛋白和透明质酸的放射免疫分析

SERUM RADIOIMMUNOASSAY OF LAMININ AND HYALURONIC ACID

采用ＲＩＡ法对１３４例肝病患者进行血清ＬＮ和ＨＡ含量的测定。结果表明：慢性肝病尤其是肝硬化患者血清中ＬＮ和ＨＡ的含量显著高于对照组（Ｐ＜０．００１），并且与肝功其它指标和肝脏的损伤程度密切相关。提示对血清进行ＬＮ和ＨＡ的ＲＩＡ联合测定可以作为判断慢性肝病患者的损伤程度和早期诊断肝纤维化的特异指标。

The assay of serum LN and HA by RIA in 134 hepatopathadic patients reveals that these patients have much higher LN and HA levels than healthy controls( P <0.001);in addition, these higher levels are closely related to the other indices of liver function and to the degree of hepatic injury. The results suggest that the level of LN and LA as a specific index can be used to diagnose early liver fibrosis and chronic diseases, especially cirrhosis.