肝炎后肝硬化血清β2-微球蛋白检测的临床意义

Clinical significance of determining serum β 2-microglobulin in patients with hepatitis associated cirrhosis

目的探讨肝炎后肝硬化病人血清β2-微球蛋白（β2-MG）水平的变化及其与病情和预后之间的关系。方法用RIA检测60例肝炎后肝硬化病人血清β2-MG。根据Child-Pugh分级标准，A级22例，B级20例，C级18例；比较Child-PughA级、B级和C级之间血清β2-MG水平。根据B超检查结果，腹水阳性26例，腹水阴性34例，比较腹水阳性和阴性之间血清β2-MG的水平。结果肝炎后肝硬化病人血清β2-MG水平，Child-PughA级显著高于B级，B级显著高于C级（P=0．001，P=0．002）；腹水阳性显著高于腹水阴性（P=0．024）。结论检测血清β2-MG浓度水平有助于肝炎后肝硬化病人的病情判断和预后估计。

Objective To explore the relationship of change of serum β 2-microglobulin （β2-MG） level with the status of the illness and the prognosis in patients with hepatitis associated cirrhosis. Methods Serum β2-MG was determined by RIA, 22 patients, 20 patients and 18 patients were in grade A, grade B and grade C, respectively, according to the Child-Pugh scores, Serum β2-MG level were compared between the patients with grade A, grade B and grade C. 26 patients and 34 patients were ascites-positive and -negative, respectively, according the B-mode ultrasonic examination. Serum β2-MG level was compared between the ascites-positive and-negative patients, Results Serum β2-MG level in patients with grade A was significantly higher than that in patients with grade B and that in patients with grade B was significantly higher than that in patients with grade C （P=0,001, P=0.002）. Serum β2-MG level in ascites-positive patients was significantly higher than that in ascites-negative patients （P=0.024）. Conclusion Determining serum β2-MG is helpful of the judging the status of the illness and evaluating the prognosis for patients with hepatitis associated cirrhosis.