大剂量胸腺素治疗类风湿性关节炎67例

Treating 67 cases of rheumatoid arthritis with high dose thymosin

目的探讨大剂量胸腺素对类风湿性关节炎（RA）临床症状及免疫指标的影响。方法将67例RA病人随机分成胸腺素组和对照组，均给予甲氨蝶呤治疗，胸腺素组同时给予胸腺素80—100mg，加入10％葡萄糖液250mL内，静脉滴注，1次/d，连续8wk。结果胸腺素组在休息痛、晨僵、关节肿胀指数及CRP指标、医生的客观评估方面与对照组比较差异有显著意义，在a-酸性糖蛋白（AAG）及病人自身评估方面与对照组比较差异有非常显著意义（P〈0．01），综合疗效评价胸腺素组也优于对照组。结论大剂量胸腺素对类风湿性关节炎治疗作用肯定，无明显不良反应，临床可作为辅助治疗手段。

Objective To explore the influence of high dose thymosin on the clinical sympotons and immunologic indexes of patients with rheumatoid arthritis. Methods 67 patients with rheumatoid arthritis were randomized into 2 groups： thymosin group （received thymosin 80-100mg in 250 mL 10% glucose, once a day, last for 8 wks） and control group, all patients received methotrexate. Results Clinic symptoms, CRP and objective evaluation made by doctors were significantly improved in thymosin group than that in control. AAG and self evaluation made by patients themselves very much significantly improved in thymosin group than that in control. Conclusion High dose thymosin could do help to rheumatoid arthritis without significant side effects, and could be recommended in adjuvant therapy of rheumatoid arthritis.