移植肾毛霉感染2例

Mucormycosis of renal allograft:report of two cases

目的探讨移植肾毛霉感染的诊断及处理方法。方法2例肾移植术后早期出现移植肾毛霉感染,1例进行手术处理及两性霉素B脂质体联合治疗,1例仅进行了手术处理。结果进行手术处理及两性霉素B脂质体高剂量(总量6.3g)、足疗程(6周)联合治疗的患者治愈,另1例在诊断明确前死亡。结论移植肾的毛霉感染较少见,病死率高,进行手术处理及两性霉素B脂质体联合治疗可以取得较好疗效。

Objective To summary the diagnosis and treatment of renal allograft mucormycosis. Methods Two cases of renal mucormycosis early after transplantation were reported. One case was managed with surgical procedures and liposomal amphotericin B, the other by surgery alone. Results The first case was cured by combination of surgical procedure and high dose liposomal amphotericin B （6.3 g） for 6 weeks. The second case died before the diagnosis was confirmed. Conclusions Renal allograft mucormycosis is rare, but the mortality is high. Surgical treatment combined with liposomal amphotericin B is success ful in managing such cases.